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The plane which was reportedly travelling between Barcelona and Dusseldorf, crashed between Barcelonnette and Digne.
According to BBC, the plane was reported to be carrying 142 passengers and 6 crew members.
Both Airbus and Germanwings have said they aware of the reports but cannot yet confirm them.
Last week, Lufthansa pilots embarked on a strike action over pension and retirement age, forcing the group's subsidiaries including Germanwings, to cover the routes affected by the strike action.
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No further details or number of casualties is known at this time.