Liverpool's Salah is huge favourite to win the award in an extraordinary debut season with the Reds which sees him top the goal charts with 29 goals and has also contributed nine assists.
Manchester United' s De Gea and Tottenham's Harry Kane have been impressive for their clubsides which has earned them a nomination for the awards.
De Gea top the goalkeeping clean sheet with 16 while Kane has a total of 25 goals in the league only behind Liverpool's Salah.
Manchester trio of De Bruyne, Silva and Sane all played pivotal roles, which sees the Blue side of Manchester on top of the table and favourites to win the league.
De Bruyne tops the assist leaders with 15 and has also contributed seven goals, Silva has 11 assists and eight goals while Sane has 12 assists and nine goals.
Nominees for the PFA Young Player of the Year award are Harry Kane of Tottenham, Ryan Sessegnon of Fulham, Manchester United's Marcus Rashford and Manchester City's trio of Leroy Sane, Raheem Sterling and Ederson Moraes.
Ederson has been impressive for Manchester City in the Premier League which has earned him a nomination for the Young Player of the Year, the Brazilian shot stopper has 14 clean sheets.
Ederson's teammate Raheem Sterling has a total of 16 league goal and has also contributed eight assists.
Manchester United's Marcus Rashford has six league goals and five assists.
Fulham's Sessgnon is the only player not in the Premier League up for the PFA Awards..